The Romanov Palace in Tashkent was built in 1891 according to the design of architects V. S. Heintzelman and A. L. Benois for Grand Duke Nikolai Konstantinovich, exiled to the outskirts of the empire - to the Turkestan region. The apartments of the Grand Duke were located in the left wing of the palace, and the apartments of his wife were located in the right wing.
Currently, the building is used as a reception house for the Ministry of Foreign Affairs of Uzbekistan. Until 1995, the St. George Church stood near the entrance to the palace territory.
Under Soviet rule, a museum was organized in the palace, since Nikolai Konstantinovich, before his death in 1918, donated the palace to the city of Tashkent with the condition of establishing a museum in the palace. The prince himself died in January 1918 from transient pneumonia.
The collection of paintings of European and Russian painting, collected by the Grand Duke and brought by him from St. Petersburg, was the basis for the creation in 1919 of the Museum of Art in Tashkent, which has one of the richest collections of paintings of European painting among the art museums of Central Asia.
Later, from the 1940s to the 1970s, in connection with the move of the Museum of Art to a new building, the Republican Palace of Pioneers and the Museum of Antiques and Jewelry Art of Uzbekistan were located here (until the early 1990s).